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| 纯镁微弧氧化载葛根素膜层的耐蚀性和体外生物活性模拟 |
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彭书浩1, 李慕勤1, 刘勇1, 王晶彦1, 李建军2, 王娇3
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1.佳木斯大学 黑龙江省高校生物医学材料重点实验室, 黑龙江 佳木斯 154007;2.佳木斯大学 机械工程学院, 黑龙江 佳木斯 154007;3.哈尔滨焊接研究院有限公司, 哈尔滨 150000
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| 摘要: |
| 为了制备一种能提高医用纯Mg微弧氧化膜层的耐蚀性和生物活性的膜层，对纯Mg表面进行超声微弧氧化（Ultrasonic micro arc oxidation，UMAO），再将不同浓度的中药提取物葛根素添加到偶联剂硅烷水解液中，通过浸渍，获得载药膜层。通过SEM观察膜层表面形貌，傅里叶红外光谱分析官能团，并进行润湿角、电化学腐蚀及模拟体液浸泡试验。结果表明：载药膜层有Si-O-Si骨架和苯环官能团产生，起到了封孔的作用，复合膜层润湿角增加了48°，自腐蚀电流降低一个数量级，阻抗提高了约188 kΩ。模拟体液浸泡膜层表面有羟基磷灰石（Hydroxylapatite，HA）生成。纯Mg经UMAO，浸渍硅烷并载葛根素（1.2 mg/mL），阻抗是UMAO组的7倍，Ca/P比达到1.55，形成的复合生物膜层具有良好的耐蚀性和生物活性。 |
| 关键词: 纯镁 超声微弧氧化 葛根素 耐蚀性 生物活性 |
| DOI：10.11933/j.issn.1007-9289.20171026001 |
| 分类号:TG174.451 |
| 基金项目:国家自然科学基金（31370979） |
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| Corrosion Resistance and Vitro Biological Activity in Simulated Body Fluid of Micro Arc Oxidation Coatings on Pure Magnesium with Puerarin |
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PENG Shu-hao1, LI Mu-qin1, LIU Yong1, WANG Jing-yan1, LI Jian-jun2, WANG Jiao3
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1.Key Biomedical Materials Laboratory of Colleges and Universities in Heilongjiang Province, Jiamusi University, Jiamusi 154007, Heilongjiang;2.College of Mechanical Engineering, Jiamusi University, Jiamusi 154007, Heilongjiang;3.Harbin Welding Institute Limited Company, Harbin 150000
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| Abstract: |
| In order to improve the corrosion resistance and bioactivity of pure magnesium (Mg) for medical application, a coating was prepared on the surface of pure Mg after ultrasonic micro arc oxidation (UMAO). Then, the UMAO coatings were impregnated in the silane coupling agent hydrolysis solution with different concentrations of puerarin (a Chinese herb extract) for a drug-loaded coating. The morphologies and functional group of the coatings were characterized using SEM and FTIR. Moreover, wetting angle test, electrochemical corrosion test and immersion test in the simulated body fluid (SBF) were employed. The results show that Si-O-Si skeleton and functional group of the benzene ring appear on the drug-loaded coatings, which seals the holes. Besides, the wetting angles increase by 48°, and the self-corrosion current decreases by one order, and the impedances increase by 188 kΩ on the coatings. Hydroxyapatite (HA) appears on the coatings after soaking in SBF.The composite coatings have a good corrosion resistance and biological activity with 1.2 mg/mL puerarin addition after impregnating silane because the impedance increases by 7 times than that of the UMAO coating and the ratio of Ca to P is 1.55. |
| Key words: pure magnesium ultrasonic micro-arc oxidation(UMAO) puerarin corrosion resistance biological activity |