| 摘要: |
| 氧化锌纳米颗粒(ZnO NPs)因其优异的压电特性在生物医学领域中得到广泛应用。通过对 ZnO 进行硅烷化改性使其表面接枝氨基，并将其掺杂在甲基丙烯酸酐化明胶、N, N-二甲基丙烯酰胺和 α-甲基丙烯酸共聚交联的水凝胶中，通过傅里叶红外光谱(FTIR)、核磁共振氢谱(1 HNMR)、扫描电镜(SEM)、流变学试验、电学表征、电感耦合等离子体质谱(ICP-MS)及抗菌试验，对水凝胶的成分、形貌、力学性能、压电性能、Zn2+释放量和抗菌性能进行分析。研究结果表明，掺杂不同浓度的改性氧化锌(KH550-ZnO)后，水凝胶储存模量均高于损耗模量且维持在 1.8~2.5 kPa；在 5 N 动态压力作用下，随着 KH550-ZnO 掺杂量的增加，材料产生的电压从 1.7 mV 上升到 30.5 mV。此外，对压电水凝胶的抗菌机理进行初步探讨，当 KH550-ZnO 的掺杂量大于 0.1% g / mL 时，水凝胶对大肠杆菌的抗菌率达到 98%以上，并证实了压电材料的压电性能可增强其抗菌性能。 |
| 关键词: 水凝胶 氧化锌 表面改性 压电性 抗菌性 |
| DOI：10.11933/j.issn.1007-9289.20210427004 |
| 分类号:O635;TQ465 |
| 基金项目:国家自然科学基金资助项目(51932002，31771080) |
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| Preparation of ZnO Doped Piezoelectric Hydrogel and Its Antibacterial Mechanism |
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DENG Weicheng1, TAN Guoxin1, TIAN Yu1, LIANG Zehui1, GUAN Youjun1, ZHOU Zhengnan1,2
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1.School of Chemical Engineering and Light Industry, Guangdong University of Technology,Guangzhou 510006 , China;2.School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641 , China
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| Abstract: |
| ZnO nanoparticles (ZnO NPs) have been widely used in biomedical fields due to their excellent piezoelectric properties. Zinc oxide is modified by silanylation to graft amino on its surface, and doped in the hydrogel of methacrylate anhydride gelatin, N, N-dimethylacrylamide and α-methacrylate copolymerization. The composition, morphology, mechanical properties, piezoelectric properties, releasing amount of Zn2+ and antibacterial properties of hydrogels are analyzed by Fourier transform infrared spectroscopy (FTIR), hydrogen nuclear magnetic resonance spectroscopy (1 HNMR), scanning electron microscopy (SEM), rheological experiments, electrical characterization, inductively coupled plasma massspectrometry(ICP-MS) and antibacterial experiments. After doping with different concentration of modified zinc oxide (KH550-ZnO), the results show that the storage modulus of the hydrogel is higher than the loss modulus and remains in the range of 1.8~2.5 kPa. Under the dynamic pressure of 5 N, the voltage generated by the material increases from 1.7 mV to 30.5 mV with the increase of the doping amount of KH550-ZnO. In addition, the antibacterial mechanism of the piezoelectric hydrogel has been preliminarily-discussed. When the doping amount of KH550-ZnO is greater than 0.1% g / mL, the antibacterial rate of the hydrogel to E.coli has reached more than 98%, and it has been confirmed that the piezoelectric properties of the piezoelectric material can enhance its antibacterial performance. |
| Key words: hydrogel zinc oxide surface modification piezoelectricity antibacterial property |
