| 摘要: |
| 为改善镁合金的骨植性能,采用微弧氧化处理和电沉积钙磷涂层相结合的方法在纯镁表面制备具有生物活性的复合涂层,研究了复合涂层在模拟体液和细胞培养液中的组织结构演化、腐蚀行为、骨形成能力和细胞粘附行为。 微弧氧化镁表面沉积的钙磷相为二水合磷酸氢钙(DCPD)。 电沉积过程中 DCPD 优先在微弧氧化层的通孔和放电通道处形核、随后长大并覆盖微弧氧化层而起到封孔作用。 涂覆后镁的低频阻抗模值在浸泡初期超过了 105 Ω·cm2 ,且在 120 h 内基本保持稳定;腐蚀电流密度与纯镁相比下降了约 3 个数量级,复合涂层显著地提高了镁的耐蚀性。 复合涂层在模拟体液和细胞培养液中均表现出了诱导羟基磷灰石(HA)沉积的能力,在细胞培养液中浸泡 14 d 后涂层表面出现球状类骨 HA 组织;细胞黏附试验中,活细胞几乎黏附在整个涂层表面,表现出良好的骨形成能力和细胞活性。 |
| 关键词: 镁 微弧氧化 电沉积 钙磷涂层 骨形成能力 生物活性 |
| DOI：10.11933/j.issn.1007-9289.20200814001 |
| 分类号:TG174.45 |
| 文章编号:1007-9289(2020)04-0102-09 |
| 文献标识码:A |
| 基金项目:国家自然科学基金 (51272055) |
|
| Preparation and Properties of Calcium Phosphate Bio-coating Formed on Micro Arc Oxidized Magnesium |
|
Han Jiaping1,2, Wang Zhenling2, Tang Shawei1, Hu Jin1, Yu Yucheng2
|
|
1.School of Materials Science and Engineering, Harbin Institute of Technology, Harbin 150001 , China;2.School of Vanadi- um and Titanium, Panzhihua University, Panzhihua 617000 , China
|
| Abstract: |
| To improve the bone implant performance of Mg alloys, composite coating with bio-activity was formed on pure Mg assisted by micro arc oxidation (MAO) and calcium phosphate coating (CaPh, fabricated by electro-deposition). Structure evo- lution, corrosion behavior, apatite formation ability and cell attachment of composite coating were investigated. Calcium hydrogen phosphate dihydrate (DCPD) is the main composition of the CaPh coating on MAO coated Mg. DCPD compounds prefer to nu- cleate at the through-holes and discharge channels of MAO layer, then grow and cover the MAO gradually, and seal the micro pores in return. The impedance modulus of the coated Mg at low frequency exceeds 105 Ω·cm2 in the initial immersion period, and maintains almost constant in 120 h. Corrosion current density decreases about 3 orders of magnitude compared to the pure Mg, indicating that the corrosion resistance is enhanced noticeably. The composite coating shows hydroxy-induced apatite deposi- tion ability in simulated body fluid(SBF) and cell culture medium. Globular bone-like HA structure appears on coating surface after 14 days of immersion in cell culture medium. Live cells adhere almost at the whole coating surface, which shows excellent apatite formation ability and cell attachment in cell adhesion test. |
| Key words: Mg micro-arc oxidation electro-deposition calcium phosphate coating apatite formation ability bio-activity |
