引用本文:纪振冰,万熠,赵梓贺,王宏卫,范世缘,刘战强.生物医用钛植入体表面微纳结构与生物活性离子对生物相容性影响研究综述[J].中国表面工程,2022,35(4):84~101
Ji Zhenbing,Wan Yi,Zhao Zihe,Wang Hongwei,Fan Shiyuan,Liu Zhanqiang.Review on the Influence of Surface Micro-nano Structure and Bioactive Ions of Biomedical Titanium Implants on Biocompatibility[J].China Surface Engineering,2022,35(4):84~101
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生物医用钛植入体表面微纳结构与生物活性离子对生物相容性影响研究综述
纪振冰1,2, 万熠1,2, 赵梓贺1,2, 王宏卫3,4, 范世缘1,2, 刘战强1,2
1.山东大学高效洁净机械制造教育部重点实验室 济南 250061;2.山东大学机械工程学院 济南 250061;3.山东大学齐鲁医院急诊科 济南 250012;4.山东大学齐鲁医院山东大学急危重症临床医学研究中心 济南 250012
摘要:
生物医用钛植入体的表面微观形貌及化学组成作为影响植入体生物相容性的重要因素,决定了植入的稳定性和使用寿命, 得到广泛研究,对钛植入体的表面改性研究现状进行系统梳理变得极为重要。针对钛植入体表面微纳米复合结构的构建及添加典型生物活性离子的研究现状进行综述,以及二者的结合对促进细胞黏附、增殖、分化和促进动物体内成骨的协同效应,简述微纳米复合结构对细胞行为的内在调控机制。结果表明,钛植入体表面的微纳米复合结构及生物活性离子对细胞的行为均表现出积极作用,兼具二者的植入体能够更好地促进细胞的黏附、增殖及分化,植入动物体内后更有利于植入体与周围组织的骨性整合。最后,根据当前生物医用钛植入体表面改性研究中存在的抗菌性能较差、对细胞的影响机制不明确等问题,提出植入体在表面改性领域的研究趋势。提出了钛植入体表面改性领域微纳结构构建和生物活性离子添加的研究现状和未来的发展方向,填补了钛植入体表面改性领域目前缺少综述文章来引领的空白,可为未来钛植入体的表面改性的发展提供借鉴。
关键词:  钛植入体  表面改性  微纳米复合结构  生物活性离子  协同作用  生物相容性
DOI:10.11933/j.issn.1007-9289.20211123002
分类号:TG146;R318
基金项目:国家自然科学基金(51975336)、山东省重点研发计划(2019JZZY010112)和山东省重点研发计划(2020JMRH0202)资助项目
Review on the Influence of Surface Micro-nano Structure and Bioactive Ions of Biomedical Titanium Implants on Biocompatibility
Ji Zhenbing1,2, Wan Yi1,2, Zhao Zihe1,2, Wang Hongwei3,4, Fan Shiyuan1,2, Liu Zhanqiang1,2
1.Key Laboratory of High-efficiency and Clean Mechanical Manufacture of Ministry of Education, Shandong University, Jinan 250061 , China;2.School of Mechanical Engineering, Shandong University, Jinan 250061 , China;3.Emergency Department, Qilu Hospital of Shandong University, Jinan 250012 , China;4.Shandong University Acute and Critical Care Clinical Medicine Research Center, Qilu Hospital of Shandong University, Jinan 250012 , China
Abstract:
As an important factor affecting the biocompatibility of implant, the surface micromorphology and chemical composition of the biomedical titanium implant determine the stability and service life of the implant, and have been widely studied. It is extremely important to systematically review the research status of surface modification of titanium implants. This paper reviews the research status of the construction of micro-nano structure on the surface of titanium implants and the addition of typical bioactive ions, and the synergistic effects of the combination of the two on promoting cell adhesion, proliferation, differentiation and promoting osteogenesis in animals. Besides, this paper briefly describes the internal regulation mechanism of micro-nano structure on cell behavior. The review indicates that the micro-nano structure and bioactive ions on the surface of titanium implants have a positive effect on the behavior of cells, and implants with both can better promote cell adhesion, proliferation and differentiation. It is more conducive to the osseointegration of the implant and the surrounding tissue after in vivo. Finally, according to the problems of poor antibacterial performance and unclear effect on cells in the current research on surface modification of biomedical titanium implants, the research trend in the field of surface modification is proposed. The research status and future development direction of micro-nano structure construction and bioactive ions addition in the field of titanium implant surface modification are proposed, This paper fills the gap in the surface modification of titanium implant and provides a reference for the future development of titanium implant surface modification.
Key words:  titanium implant  surface modification  micro-nano structure  bioactive ions  synergistic effect  biocompatibility
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