| 摘要: |
| 聚四氟乙烯（PTFE）具有良好的生物稳定性，是一种被广泛应用的生物材料。利用聚多巴胺（PDA）化学及原位共沉积法，在PTFE基板表面沉积制备复合薄膜，以改善其表面的亲水性和细胞响应特性。研究结果显示，由PDA和TiO2构成的薄膜可以有效地沉积与PTFE基板表面。薄膜均匀且与基板结合牢固，剪切强度可达23.5 MPa。薄膜中的TiO2含量可以通过沉积液中的TiO2水溶胶加入量调节。具有薄膜的PTFE表面成纤维细胞和成骨细胞响应性较之PTFE基板显著改进，1 d的细胞粘附试验和3 d的细胞增殖试验均显示涂层表面细胞数量显著高于无涂层的PTFE。这种在PTFE表面构建二氧化钛涂层的方法简单易行，在PTFE植入体表面修饰方面具有较好的应用前景。 |
| 关键词: PDA/TiO2复合薄膜 细胞响应性 聚四氟乙烯 表面改性 |
| DOI：10.11933/j.issn.1007-9289.20190415002 |
| 分类号:TG174.44 |
| 基金项目:国家自然科学基金（51872259） |
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| Preparation of PDA/TiO2 Composite Film on PTFE and Its Cellular Response |
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HE Xuzhao, HU Huiwen, ZHU Yifei, CHENG Kui, WENG Wenjian
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School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China
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| Abstract: |
| Polytetrafluoroethylene (PTFE) has been widely applied as a biomaterial owing to its good stability and bioinertness. A PDA/TiO2 composite film was prepared on the surface of PTFE substrate through polydopamine (PDA) assisted in-situ co-deposition, so that the hydrophilicity and cellular responses could be improved. It was found that the film consists of PDA and TiO2. The content of TiO2 in the film can be controlled through the amount of TiO2 sol added in the deposition solution. The film is bonded to the substrate strongly. The shear strength reaches 23.5 MPa. Fibroblasts and osteoblasts are seeded on the surface of the modified substrate, and one-day cell adhesion and three-day proliferation experiments show that the cellular response of the modified substrate are significantly improved. Such deposition method is simple and easy, exhibiting wide potential in surface modification of PTFE for biomedical application. |
| Key words: PDA/TiO2 composite film cellular responses PTFE surface modification |
