| 摘要: |
| 传统的抗生素治疗细菌感染往往会导致细菌对抗生素产生耐药性，导致耐药细菌的形成，从而对人类健康产生更大的危害。设计了一种新颖的表面系统，其可在不使用抗生素的情况下为钛植入体提供一种可靠的自抗菌平台。这一特性的实现依靠于钛植入体表面PDA（polydopamine）/RGDC（arginine-glycine-aspartic acid-cysteine）/氧化锌量子点（ZnO QDs）复合涂层的构建，通过粒子生长法得到的ZnO QDs经RGDC修饰后连接到覆盖于钛植入物表面的PDA。用不同的细菌和小鼠成骨细胞对此涂层进行了测试，结果表明，文中设计的复合涂层对大肠杆菌的抗菌率高达98.95%，同时具有优异的生物相容性。因此，该表面涂层在生物医用植入材料领域将有着广泛的应用前景。 |
| 关键词: 植入体 抗菌 生物相容性 氧化锌量子点 RGDC肽 |
| DOI：10.11933/j.issn.1007-9289.20190319004 |
| 分类号:TG174.444 |
| 基金项目:湖北省自然科学基金（2018CFA064）；国家重点研发计划（2016YFC1100600） |
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| Construction of PDA/RGDC/Zinc Oxide Quantum Dot Composite Coatings with Antibacterial Activity and Biocompatibility on Surface of Titanium Implants |
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YU Yi1, XIANG Yiming1, LI Yilang1, TAN Lei1, LIU Xiangmei1, WU Shuilin2
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1.School of Materials Science and Engineering, Hubei University, Wuhan 430062, China;2.School of Materials Science and Engineering, Tianjin University, Tianjin 300072, China
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| Abstract: |
| Traditional antibiotics to treat bacterial infections often lead to bacterial resistance to antibiotics, leading to the formation of drug-resistant bacteria, which has a greater risk to human health. A novel surface system was designed to provide a reliable self-antimicrobial platform for titanium implants without the use of antibiotics. This feature was achieved by constructing the composite coating on PDA(polydopamine)/RGDC (arginine-glycine-aspartic acid-cysteine)/zinc oxide quantum dot (ZnO QDs) on titanium implant surface. The ZnO QDs obtained by particle growth method was modified by RGDC and connected to the PDA covering the surface on titanium implant. The composite coating was tested with different bacteria and mouse osteoblasts. The results show that it has an antibacterial rate against Escherichia coli up to 98.95% and has excellent biocompatibility. Hence, the surface coating will have a broad application prospect in the field of biomedical implant materials. |
| Key words: implants antibacterial biocompatibility zinc oxide quantum (ZnO QDs) arginine-glycine-aspartic acid-cysteine (RGDC) peptides |
