引用本文:韩亚宁,刘涵云,冯卫华,马洪超,杨丽敏,姜磊.聚去甲肾上腺素构建的多功能仿生表界面∗[J].中国表面工程,2021,34(3):40~58
HAN Yaning,LIU Hanyun,FENG Weihua,MA Hongchao,YANG Limin,JIANG Lei.Multifunctional Biomimetic Surface Constructed by Polynorepinephrine[J].China Surface Engineering,2021,34(3):40~58
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聚去甲肾上腺素构建的多功能仿生表界面∗
韩亚宁1, 刘涵云2, 冯卫华2, 马洪超1, 杨丽敏1, 姜磊1
1.中国石油大学(华东)化学工程学院重质油国家重点实验室及生物工程与技术中心 青岛 266580;2.青岛大学附属医院 青岛 266003
摘要:
贻贝的足丝可以分泌出贻贝黏附蛋白,使其在潮湿的海洋环境中也可以牢牢黏附在各种物体表面。 聚去甲肾上腺素 (PNE)是类似于贻贝足丝结构的仿生材料,具有制备工艺简单、生物相容性好、黏合性强、易于功能化、光热转换效率高等特点,它可以由去甲肾上腺素(NE)单体在弱碱性 pH 环境中自发聚集形成。 此外,NE 能够在绝大多数材质的基底上聚集成纳米尺度的 PNE 薄膜,产生亲水性强、化学性能稳定、生物相容性优良的仿生表界面。 近年来,基于 PNE 优异的物化性质构建多功能的纳米平台,并开始被用于组织工程、生物传感、电极优化、癌症治疗等应用领域。 这篇综述对近年来 PNE 的结构、性能和应用研究进行分类介绍、分析和总结,并对其存在的挑战和未来发展前景进行讨论和展望。
关键词:  聚去甲肾上腺素  表面修饰  生物仿生  表面工程
DOI：10.11933/j.issn.1007-9289.20201208001
分类号:O629
基金项目:山东省自然科学基金(ZR2017LB028)、山东省重点研发计划 (2018GSF118032)和中央高校基本科研业务费专项资金(18CX02125A)资助项目
Multifunctional Biomimetic Surface Constructed by Polynorepinephrine
HAN Yaning1, LIU Hanyun2, FENG Weihua2, MA Hongchao1, YANG Limin1, JIANG Lei1
1.State Key Laboratory of Heavy Oil Processing and Center for Bioengineering and Biotechnology,College of Chemical Engineering, China University of Petroleum (East China), Qingdao 266580 , China;2.The Affiliated Hospital of Qingdao University, Qingdao 266003 , China
Abstract:
Mussels can secrete adhesion proteins, which allow them to adhere firmly to various surfaces even in humid marine environments. Polynorepinephrine (PNE) is a mussel-inspired biomimetic material with many desirable properties, such as simple preparation process, good biocompatibility, strong adhesion, easy functionalization, and high efficiency in photothermal conversion. It can be formed by the selfassembly of norepinephrine (NE) monomers in weak pH environment. In addition, NE is able to aggregate and form nanoscale PNE film on most substrates, providing the bionic surfaces with strong hydrophilicity, chemical stability, and excellent biocompatibility. In recent years, the multifunctional nanoplatforms have been constructed based on the excellent physicochemical properties of PNE, with wide application in tissue engineering, biosensing, electrode optimization, cancer therapy, etc. This review focused on the fundamental structure, properties, and application of PNE, with a view to discussing the challenges and future of PNE research.
Key words:  polynorepinephrine  surface finishing  biomimicry  surface engineering
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