引用本文:周正难,代聪,张凤苗,谭帼馨,宁成云.聚吡咯改性聚偏氟乙烯膜的电学特性及生物相容性[J].中国表面工程,2019,32(5):37~44
ZHOU Zhengnan,DAI Cong,ZHANG Fengmiao,TAN Guoxin,NING Chengyun.Electrical Property and Biocompatibility of Polyvinylidene Fluoride Films Modified by Polypyrrole[J].China Surface Engineering,2019,32(5):37~44
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聚吡咯改性聚偏氟乙烯膜的电学特性及生物相容性
周正难1, 代聪1, 张凤苗1, 谭帼馨1, 宁成云2
1.广东工业大学 轻工化工学院, 广州 510006;2.华南理工大学 材料科学与工程学院, 广州 510641
摘要:
聚偏氟乙烯因具有生物相容性、压电性及良好的机械性能而在生物医用中备受关注。利用电化学法在聚偏氟乙烯膜表面沉积聚吡咯涂层以表面改性聚偏氟乙烯膜，研究了聚吡咯纳米颗粒和纳米线结构涂层对聚偏氟乙烯膜的表面亲水性、电学特性及生物相容性的影响。采用扫描电镜和原子力显微镜观察了纳米结构聚吡咯涂层改性聚偏氟乙烯膜的表面形貌；利用表面接触角测量仪、原子力显微镜研究了改性聚偏氟乙烯膜的亲水性和电学特性；通过体外矿化、细胞死活染色和CCK-8检测方法探讨了改性聚偏氟乙烯膜的生物相容性。结果表明：纳米结构聚吡咯涂层改性聚偏氟乙烯膜的表面亲水性、表面电势分布及生物相容性明显提高了，有利于表面类骨矿物的沉积及细胞的粘附与增殖。此外，纳米线结构聚吡咯改性的聚偏氟乙烯膜具有更高的亲水性、表面电势分布，更有利于细胞粘附与增殖。
关键词:  聚吡咯  聚偏氟乙烯  电学特性  生物相容性
DOI：10.11933/j.issn.1007-9289.20190416001
分类号:TG174.44
基金项目:国家自然科学基金（51772106， 51702104， 31771080）；中国博士后科学基金（2017M622641）
Electrical Property and Biocompatibility of Polyvinylidene Fluoride Films Modified by Polypyrrole
ZHOU Zhengnan1, DAI Cong1, ZHANG Fengmiao1, TAN Guoxin1, NING Chengyun2
1.Institute of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China;2.School of Materials Science and Engineering, South China University of Technology, Guangzhou 510641, China
Abstract:
Polyvinylidene fluoride (PVDF) has attracted much attention due to its biocompatibility, piezoelectric and favourable mechanical properties. The modification of polypyrrole coating on the surface of the PVDF film by electrochemical method was studied. The surface morphology of the nanostructured polypyrrole coating modified PVDF film was observed by scanning electron microscopy (SEM) and atomic force microscope (AFM). The surface contact angle analyzer and AFM were used to study the hydrophilicity and electrical properties of the PVDF membrane modified by the nano structure polypyrrole coating. The biocompatibility of the nanostructured polypyrrole coating modified PVDF membrane was investigated by in vitro mineralization, cell viability staining and CCK-8 assay, respectively. The results show that the surface hydrophilicity, surface potential distribution and biocompatibility of PVDF films are significantly improved by the modification of the nanostructured polypyrrole coating, and more conducive to the surface bone mineral deposition and cell adhesion and proliferation. In addition, the PVDF membrane modified by polypyrrole nanowire has higher hydrophilicity and surface potential distribution, which is more conducive to cell adhesion and proliferation.
Key words:  polypyrrole  polyvinylidene fluoride  electrical property  biocompatibility
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